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研究表明 致命蜘蛛毒液可減輕中風帶來的影響

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A protein in spider venom may help protect the brain from injury after a stroke, according to research.

研究表明,蜘蛛毒液中的一種蛋白質或許能夠保護大腦免受中風帶來損傷。

Scientists found a single dose of the protein Hi1a worked on lab rats. They said it showed "great promise as a future stroke treatment" but had not yet been tested in human trials.

科學家們發現一劑量的Hi1a蛋白質在小白鼠身上起了作用。他們表示,這種蛋白質“作爲未來的中風治療手段大有前途”,不過尚未進行人體試驗。

The Stroke Association said the research was at its early stages but it would "welcome any treatment that has the potential to reduce the damage caused by stroke".

中風協會表示,該研究尚處於早期階段,不過該協會“樂於接受任何可能降低中風損傷的治療手段”。

The researchers, from the University of Queensland and Monash University, travelled to Fraser Island in Australia to hunt for and capture three potentially deadly Australian funnel web spiders.

來自昆士蘭大學和莫納什大學的研究者們奔赴澳大利亞的費沙島,尋找並捕獲了三種可能符合條件的、可致死的澳大利亞漏斗網蜘蛛。

研究表明 致命蜘蛛毒液可減輕中風帶來的影響

They then took the spiders back to their laboratory "for milking". This involved coaxing the spider to release its venom, which can then be sucked up using pipettes.

之後他們將這些蜘蛛帶回自己的實驗室進行“擠乳”操作。這項操作包括誘騙蜘蛛釋放毒液,接着用吸管吸取這些毒液。

The scientists honed in on a protein in the venom and recreated a version of it in their lab. They then injected this Hi1a into the lab rats.

科學家們仔細研究了毒液中的一種蛋白質,並在實驗室中人工製造了這種蛋白。然後他們將這種名爲Hi1a的蛋白質注射進小白鼠體內。

They found that the protein blocked acid-sensing ion channels in the brain - something the researchers say are key drivers of brain damage after stroke.

他們發現,這種蛋白質阻斷了腦部的酸敏感離子通道--研究者們稱這種通道是導致中風後腦損傷的關鍵因素。

Prof Glenn King, who led the research, said the protein showed "great promise as a future stroke treatment".

領導這項研究的格倫·金教授表示,這種蛋白質“作爲未來的中風治療手段大有前途”。

"We believe that we have, for the first time, found a way to minimise the effects of brain damage after a stroke. Hi1a even provides some protection to the core brain region most affected by oxygen deprivation, which is generally considered unrecoverable due to the rapid cell death caused by stroke."

“我們相信我們已經率先找到了一種減小中風後腦損傷影響的辦法。Hi1a甚至爲腦部核心區域由缺氧帶來的絕大部分影響提供了保護措施,由於中風會導致細胞的迅速死亡,通常認爲這一損害是無法恢復的。”

The research was published in Proceedings of the National Academy of Sciences.

這項研究發表在了美國科學院論文集上。